Fig. 1

The experimental process. CUMS: the procedure of chronic unpredictable stress from 2nd day to 43rd day; BT: behavioral test on the day 1, day 22, day 29, day 36 and day 43; 5Â mg venlafaxine group: the animal received venlafaxine at a dose of 5Â mg/day from day 22 to day 43; 10Â mg venlafaxine group: the animal received venlafaxine at a dose of 10Â mg/day from day 22 to day 43