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  1. Ligand of NUMB protein-X 1 (LNX1) and LNX2 proteins are closely related PDZ domain-containing E3 ubiquitin ligases that interact with and potentially modulate numerous synaptic and neurodevelopmentally importa...

    Authors: Laura Cioccarelli, Joan A. Lenihan, Leah G. Erwin and Paul W. Young
    Citation: Behavioral and Brain Functions 2025 21:13
    Content type: Research Published on:

  2. Cerebral large artery and small vessel diseases are considered substrates of neurological disorders. We explored how the mechanisms of neurovascular uncoupling, dysfunctional blood–brain-barrier (BBB), comprom...

    Authors: Joseph A. Ackah, Xuelong Li, Huixing Zeng and Xiangyan Chen
    Citation: Behavioral and Brain Functions 2025 21:12
    Content type: Review Published on:

  3. The health risks associated with acute noise exposure are increasing, particularly the risk of mental health. This study aims to identify the association between acute high-intensity noise exposure and anxiety...

    Authors: Yifei Song, Haoyu Zhang, Xiaoni Wang, Lei Huang, Yiting Kang, Zeguo Feng, Fadong Zhao, Hongwei Zhuang and Jianbao Zhang
    Citation: Behavioral and Brain Functions 2025 21:11
    Content type: Research Published on:

  4. The objective of this review study is to examine the combined antidepressant effects of exercise and polyphenol supplementation, with a focus on specific polyphenolic compounds such as crocin, curcumin, and qu...

    Authors: Shihong Jie, Aili Fu, Chuan Wang and Sogand Rajabi
    Citation: Behavioral and Brain Functions 2025 21:10
    Content type: Review Published on:

  5. Neuroplasticity, a phenomenon present throughout the lifespan, is thought to be influenced by physical training. However, the relationship between neuroplastic differences and attentional abilities remains unc...

    Authors: Jian Wang, Siyu Gao, Junfu Tian, Hao Hong and Chenglin Zhou
    Citation: Behavioral and Brain Functions 2025 21:9
    Content type: Research Published on:

  6. Alzheimer’s disease (AD) is characterized by memory decline and mood alterations. A growing body of evidence implicates stress and other social determinants of health as potential contributors to the progressi...

    Authors: Patrick R. Suman, Grasielle C. Kincheski, Rudimar L. Frozza, Fernanda G. De Felice and Sergio T. Ferreira
    Citation: Behavioral and Brain Functions 2025 21:8
    Content type: Research Published on:

  7. Alzheimer's disease (AD) is characterized by progressive cognitive decline and synaptic dysfunction, largely driven by amyloid plaques and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Th...

    Authors: Narjes Khatoun Shabani Sadr, Fatemeh Bakhtiarzadeh, Koorosh Shahpasand, Javad Mirnajafi-Zadeh and Mehrdad Behmanesh
    Citation: Behavioral and Brain Functions 2025 21:7
    Content type: Research Published on:

  8. Major depressive disorder is a significant global cause of disability, particularly among adolescents. The dopamine system and nearby neuroinflammation, crucial for regulating mood and processing rewards, are ...

    Authors: Zi-Wei Zhao, Yun-Chen Wang, Pei-Chun Chen, Shun-Fen Tzeng, Po-See Chen and Yu-Min Kuo
    Citation: Behavioral and Brain Functions 2025 21:6
    Content type: Research Published on:

  9. Mild traumatic brain injury (mTBI) poses a significant public health concern, particularly regarding repetitive injury, with outcomes ranging from acute neurobehavioral deficits to long-term impairments. While...

    Authors: Lauren P. Giesler, William T. O’Brien, Jesse Bain, Gershon Spitz, Emily J. Jaehne, Maarten van den Buuse, Sandy R. Shultz, Richelle Mychasiuk and Stuart J. McDonald
    Citation: Behavioral and Brain Functions 2025 21:5
    Content type: Research Published on:

  10. Neuronal plasticity within the basolateral amygdala (BLA) is fundamental for fear learning. Metaplasticity, the regulation of plasticity states, has emerged as a key mechanism mediating the subsequent impact o...

    Authors: Joyeeta Dutta Hazra, Kuldeep Shrivastava, Lisa-Sophie Wüstner, Rachel Anunu, Erez Chervinsky, Somoday Hazra, Simone Beuter, Martin Kriebel, Mouna Maroun, Hansjuergen Volkmer and Gal Richter-Levin
    Citation: Behavioral and Brain Functions 2025 21:4
    Content type: Research Published on:

  11. Sleep deprivation significantly impairs cognitive function, which disrupts daily life. However, sex differences in these impairments are not well understood, as most preclinical studies primarily use male anim...

    Authors: Yiwen Zhang, Fang Chen, Mubiao Yu, Yinghui Li, Shanguang Chen, Muhammad Iqbal Choudhary, Xinmin Liu and Ning Jiang
    Citation: Behavioral and Brain Functions 2025 21:3
    Content type: Research Published on:

  12. Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disorder that is the leading cause of dementia. The underlying mechanisms of AD have not yet been completely explored. Neuroinflammatio...

    Authors: Xiang Li, Qingyong Ding, Xinxin Wan, Qilong Wu, Shiqing Ye and Yongliang Lou
    Citation: Behavioral and Brain Functions 2025 21:2
    Content type: Research Published on:

  13. Gene-environment interactions in the postnatal period have a long-term impact on neurodevelopment. To effectively assess neurodevelopment in the mouse, we developed a behavioural pipeline that incorporates sev...

    Authors: Sarah Asbury, Jonathan K. Y. Lai, Kelly C. Rilett, Zeeshan Haqqee, Benjamin C. Darwin, Jacob Ellegood, Jason P. Lerch and Jane A. Foster
    Citation: Behavioral and Brain Functions 2025 21:1
    Content type: Research Published on:

  14. Reward cues have long been considered to enhance creative performance; however, little is known about whether rewards can affect creative problem solving by manipulating states of flexibility and persistence. ...

    Authors: Can Cui, Yuan Yuan and Yingjie Jiang
    Citation: Behavioral and Brain Functions 2024 20:37
    Content type: Research Published on:

  15. The large-conductance calcium- and voltage-activated potassium (BK) channels, encoded by the KCNMA1 gene, play important roles in neuronal function. Mutations in KCNMA1 have been found in patients with various ne...

    Authors: Hiroyuki Ohta, Takashi Nozawa, Kohki Higuchi, Andrea L. Meredith, Yuji Morimoto, Yasushi Satoh and Toshiaki Ishizuka
    Citation: Behavioral and Brain Functions 2024 20:36
    Content type: Research Published on:

  16. Playing video games, especially games with action-based mechanics, is correlated with better cognitive performance, yet these performance advantages may originate from intrinsic factors such as earlier life co...

    Authors: Tina T. Vo, Shandell Pahlen, Anqing Zheng, Sian Yu, Emery Lor, Nicholas D. Bowman, Robin P. Corley, Naomi P. Friedman, Sally J. Wadsworth and Chandra A. Reynolds
    Citation: Behavioral and Brain Functions 2024 20:35
    Content type: Research Published on:

  17. Early life stress (ELS) during the stress hypo-responsive period (SHRP) alters the curiosity-like behavior later during adolescence. Previous studies have shown maternal separation (MS) stress-induced heighten...

    Authors: Shruthi S. Sharma, Arun Sasidharan, D. Yoganarasimha and T. R. Laxmi
    Citation: Behavioral and Brain Functions 2024 20:34
    Content type: Research Published on:

  19. Animals exhibit a wide range of social behaviors, including positive actions that promote social cohesion and negative behaviors associated with asserting dominance. While these behaviors are often viewed as o...

    Authors: Chih-Lin Lee, Yu-Shan Su, Chi-Yu Chang, Tzu-Yun Kung, Yu-Kai Ma, Pei-Yun Zeng, Ching-Chuan Cheng, Yu-Jen Chang, Yu-Ju Chou and Tsung-Han Kuo
    Citation: Behavioral and Brain Functions 2024 20:32
    Content type: Research Published on:

  20. Mood disorders, particularly depression and anxiety, are associated with zinc dyshomeostasis and aberrant GABAergic signaling. Activation of ZnR/GPR39 by synaptic zinc in the hippocampus triggers phosphorylati...

    Authors: Romi Sagi, Moumita Chakraborty, Milos Bogdanovic, Hila Asraf, Israel Sekler, Ora Kofman, Hagit Cohen and Michal Hershfinkel
    Citation: Behavioral and Brain Functions 2024 20:31
    Content type: Research Published on:

  21. Cutibacterium acnes(C. acnes), a Gram-positive anaerobe and a dominant bacterium species in the sebaceous follicles of the face was detected in the brain of Alzheimer’s disease (AD) patients. It has been found th...

    Authors: Morteza Aliashrafi, Mohammad Nasehi, Seyed Davar Siadat, Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani, Hakimeh Zali and Zahra Niknam
    Citation: Behavioral and Brain Functions 2024 20:30
    Content type: Research Published on:

  22. Neural entrainment has become a popular technique to non-invasively manipulate brain rhythms via external, periodic stimulation. However, there is still debate regarding its underlying mechanisms and effects o...

    Authors: Maëlan Q. Menétrey and David Pascucci
    Citation: Behavioral and Brain Functions 2024 20:29
    Content type: Research Published on:

  23. The cannabigerol derivative VCE-003.2, which has activity at the peroxisome proliferator-activated receptor-γ has afforded neuroprotection in experimental models of Parkinson’s disease (PD) based on mitochondr...

    Authors: Sonia Burgaz, Elisa Navarro, Santiago Rodríguez-Carreiro, Carmen Navarrete, Martin Garrido-Rodríguez, Isabel Lastres-Becker, Julia Chocarro, José L. Lanciego, Eduardo Muñoz and Javier Fernández-Ruiz
    Citation: Behavioral and Brain Functions 2024 20:28
    Content type: Research Published on:

  24. Nicotine dependence is associated with glutamatergic neurotransmission in the caudate and putamen (CPu) of the forebrain which includes alterations in the structure of dendritic spines at glutamate synapses. T...

    Authors: Sunghyun Kim, Sumin Sohn and Eun Sang Choe
    Citation: Behavioral and Brain Functions 2024 20:27
    Content type: Research Published on:

  25. Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is significantly increasing, resulting in severe distress. The approved treatment for ASD only partially improves the sympoms, but ...

    Authors: Eman A. E. Farrag, Mona H. Askar, Zienab Abdallah, Safinaz M. Mahmoud, Eman A. Abdulhai, Eman Abdelrazik, Eman Mohamad El Nashar, Faten Mohammed Alasiri, Asma Nasser Saeed Alqahtani, Mamdouh Eldesoqui, Ali M. Eldib and Alshimaa Magdy
    Citation: Behavioral and Brain Functions 2024 20:26
    Content type: Research Published on:

  26. Recent research has indicated that parental use of central nervous system-targeting medications during periconceptional periods may affect offspring across various developmental and behavioral domains. The pre...

    Authors: Guangyuan Fan, Tao Pan, Xingyu Ji, Changyou Jiang, Feifei Wang, Xing Liu, Lan Ma and Qiumin Le
    Citation: Behavioral and Brain Functions 2024 20:25
    Content type: Research Published on:

  27. Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with heterogeneous symptomatology. Arguably, the most pervasive shortfall of ASD are the deficits in sociability and the animal models ...

    Authors: Jakub Szabó, Emese Renczés, Veronika Borbélyová, Daniela Ostatníková and Peter Celec
    Citation: Behavioral and Brain Functions 2024 20:24
    Content type: Research Published on:

  29. Gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter in the human brain, has long been considered essential in human behavior in general and learning in particular. GABA concentration...

    Authors: Hong Li, Geraldine Rodríguez-Nieto, Sima Chalavi, Caroline Seer, Mark Mikkelsen, Richard A. E. Edden and Stephan P. Swinnen
    Citation: Behavioral and Brain Functions 2024 20:22
    Content type: Review Published on:

  30. The Duchenne and Becker muscular dystrophies (DMD, BMD) are neuromuscular disorders commonly associated with diverse cognitive and behavioral comorbidities. Genotype–phenotype studies suggest that severity and...

    Authors: Rubén Miranda, Léa Ceschi, Delphine Le Verger, Flora Nagapin, Jean-Marc Edeline, Rémi Chaussenot and Cyrille Vaillend
    Citation: Behavioral and Brain Functions 2024 20:21
    Content type: Research Published on:

  31. This study investigated the effects of repetitive unihemispheric concurrent dual-site anodal transcranial direct current stimulation (a-tDCSUHCDS) associated with the use of virtual reality games (VR) on the moto...

    Authors: Nasrin Shahbazi, Ali Heirani, Ehsan Amiri and Daniel Gomes da Silva Machado
    Citation: Behavioral and Brain Functions 2024 20:20
    Content type: Research Published on:

  32. Caffeine is a widely used drug that broadly affects human cognition and brain function. Caffeine acts as an antagonist to the adenosine receptors in the brain. Previous anecdotal reports have also linked caffe...

    Authors: Elias Vincent Hartmann, Carolin Franziska Reichert and Manuel Spitschan
    Citation: Behavioral and Brain Functions 2024 20:19
    Content type: Review Published on:

  34. Left-handedness is a condition that reverses the typical left cerebral dominance of motor control to an atypical right dominance. The impact of this distinct control — and its associated neuroanatomical peculi...

    Authors: Esteban Villar-Rodríguez, Lidón Marin-Marin, César Avila and Maria Antònia Parcet
    Citation: Behavioral and Brain Functions 2024 20:17
    Content type: Research Published on:

  35. An intronic deletion within intron 2 of the DCDC2 gene encompassing the entire READ1 (hereafter, READ1d) has been associated in both children with developmental dyslexia (DD) and typical readers (TRs), with inter...

    Authors: Sara Mascheretti, Filippo Arrigoni, Alessio Toraldo, Alice Giubergia, Chiara Andreola, Martina Villa, Valentina Lampis, Roberto Giorda, Marco Villa and Denis Peruzzo
    Citation: Behavioral and Brain Functions 2024 20:16
    Content type: Research Published on:

  36. The Default Mode Network (DMN) is a central neural network, with recent evidence indicating that it is composed of functionally distinct sub-networks. Methylphenidate (MPH) administration has been shown before...

    Authors: Maryana Daood, Noa Magal, Leehe Peled-Avron, Michael Nevat, Rachel Ben-Hayun, Judith Aharon-Peretz, Rachel Tomer and Roee Admon
    Citation: Behavioral and Brain Functions 2024 20:15
    Content type: Research Published on:

  37. Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accomp...

    Authors: George D. Dalton, Stephen K. Siecinski, Viktoriya D. Nikolova, Gary P. Cofer, Kathryn J. Hornburg, Yi Qi, G. Allan Johnson, Yong-Hui Jiang, Sheryl S. Moy and Simon G. Gregory
    Citation: Behavioral and Brain Functions 2024 20:14
    Content type: Research Published on:

  38. Macular degeneration of the eye is a common cause of blindness and affects 8% of the worldwide human population. In adult cats with bilateral lesions of the central retina, we explored the possibility that mot...

    Authors: Anna Kozak, Marco Ninghetto, Michał Wieteska, Michał Fiedorowicz, Marlena Wełniak-Kamińska, Bartosz Kossowski, Ulf T. Eysel, Lutgarde Arckens and Kalina Burnat
    Citation: Behavioral and Brain Functions 2024 20:13
    Content type: Research Published on:

  39. Subjective cognitive decline (SCD) is an early stage of dementia linked to Alzheimer's disease pathology. White matter changes were found in SCD using diffusion tensor imaging, but there are known limitations ...

    Authors: Yi-Chia Wei, Yi-Chia Kung, Ching-Po Lin, Chih-Ken Chen, Chemin Lin, Rung-Yu Tseng, Yao-Liang Chen, Wen-Yi Huang, Pin-Yuan Chen, Shin-Tai Chong, Yu-Chiau Shyu, Wei-Chou Chang and Chun-Hung Yeh
    Citation: Behavioral and Brain Functions 2024 20:12
    Content type: Research Published on:

  40. Procrastination is universally acknowledged as a problematic behavior with wide-ranging consequences impacting various facets of individuals’ lives, including academic achievement, social accomplishments, and ...

    Authors: Xiaotian Zhao, Rong Zhang and Tingyong Feng
    Citation: Behavioral and Brain Functions 2024 20:11
    Content type: Research Published on:

    The Correction to this article has been published in Behavioral and Brain Functions 2024 20:23

  41. Episodic memory (EM) deteriorates as a result of normal aging as well as Alzheimer’s disease. The neural underpinnings of such age-related memory impairments in older individuals are not well-understood. Altho...

    Authors: Shaokun Zhao, Feng Sang, Chen Liu, Fei Wang, Jiawen Liu, Chuansheng Chen, Jun Wang, Xin Li and Zhanjun Zhang
    Citation: Behavioral and Brain Functions 2024 20:10
    Content type: Research Published on:

  42. In the present study, we investigated the effect of high-intensity interval training (HIIT) on cognitive behaviors in female rats with a high-fat diet + streptozotocin (STZ)-induced type 2 diabetes.

    Authors: Kayvan Khoramipour, Maryam Hossein Rezaei, Amirhossein Moslemizadeh, Mahdieh Sadat Hosseini, Narjes Ebrahimnezhad and Hamideh Bashiri
    Citation: Behavioral and Brain Functions 2024 20:9
    Content type: Research Published on:

  43. One important role of the TPJ is the contribution to perception of the global gist in hierarchically organized stimuli where individual elements create a global visual percept. However, the link between clinic...

    Authors: Johannes Rennig, Christina Langenberger and Hans-Otto Karnath
    Citation: Behavioral and Brain Functions 2024 20:8
    Content type: Research Published on:

  44. Alzheimer’s disease (AD) and amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) are debilitating neurodegenerative diseases for which there are currently no cures. Familial cases with known geneti...

    Authors: Daniel Daudelin, Anna Westerhaus, Nan Zhang, Erica Leyder, Alena Savonenko and Shanthini Sockanathan
    Citation: Behavioral and Brain Functions 2024 20:7
    Content type: Research Published on:

  45. Spatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are limited, emphasizing the need for innovative therapeutic strategies. This...

    Authors: Raquel Sánchez-Varo, Alexander López-Salas, Rasiel Beltran-Casanueva, Estela Díaz-Sánchez, Jose Erik Alvarez-Contino, Miguel Angel Barbancho-Fernández, Pedro Serrano-Castro, Kjell Fuxe, Dasiel O. Borroto-Escuela, Natalia García-Casares and Manuel Narváez
    Citation: Behavioral and Brain Functions 2024 20:6
    Content type: Research Published on:

  46. Fruit fly courtship behaviors composed of a series of actions have always been an important model for behavioral research. While most related studies have focused only on total courtship behaviors, specific co...

    Authors: Ching-Hsin Chen, Yu-Chiao Lin, Sheng-Hao Wang, Tsung-Han Kuo and Hung-Yin Tsai
    Citation: Behavioral and Brain Functions 2024 20:5
    Content type: Methodology Published on:

  47. Visual-motor integration (VMI) is an essential skill in daily life. The present study aimed to use functional near-infrared spectroscopy (fNIRS) technology to explore the effective connectivity (EC) changes am...

    Authors: Wenchen Wang, Haimei Li, Yufeng Wang, Lu Liu and Qiujin Qian
    Citation: Behavioral and Brain Functions 2024 20:4
    Content type: Research Published on:

  48. Aging affects anxiety levels in rats while the pineal gland, via its hormone melatonin, could modulate their inherited life “clock.” The present study aimed to explore the impact of plasma melatonin deficiency...

    Authors: Jana Tchekalarova, Desislava Krushovlieva, Petj Ivanova, Zlatina Nenchovska, Gergana Toteva and Milena Atanasova
    Citation: Behavioral and Brain Functions 2024 20:3
    Content type: Research Published on:

  49. Autism spectrum disorder is one of the most common neurodevelopmental conditions associated with sensory and social communication impairments. Previous neuroimaging studies reported that atypical nodal- or net...

    Authors: Yurim Jang, Hyoungshin Choi, Seulki Yoo, Hyunjin Park and Bo-yong Park
    Citation: Behavioral and Brain Functions 2024 20:2
    Content type: Research Published on:
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Behavioral and Brain Functions

ISSN: 1744-9081

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