Fig. 5

Effects of SBF on pathological changes in the hippocampus and cerebral cortex induced by composited Aβ in rats. Representative images of hippocampal and cerebral cortical neurons stained with HE. A1–E1 Hippocampus ×40; A2–E2 Hippocampus CA1 ×400; A3–E3 Cerebral cortex ×400. A1–A3 Sham-operated group; B1–B3 Composited Aβ-treated group; showing loss of neurons, neurofibrillary degeneration (→), neuronophagia (←), nuclear pyknosis (↗), nuclear margination (↙), colliquative necrosis (★)with disrupted cellular membranes. Nuclei were fragmented, and large numbers of inflammatory cells infiltrated regions of the cerebral cortex in composited Aβ-treated rats. C1–C3 SBF 35 mg/kg group; D1–D3 SBF 70 mg/kg group; E1–E3 SBF 140 mg/kg group. Scale bar 10 or 100 µm