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Fig. 3 | Behavioral and Brain Functions

Fig. 3

From: Transcriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability

Fig. 3

Mature oligodendrocytes and microglia from Male Low Social (ML) and Female High Social (FH) C58/J amygdala demonstrate the greatest number of differentially expressed SFARI ASD risk genes. (A) Volcano plots showing differentially expressed genes (DEGs) obtained in microglia and mature oligodendrocytes when C58/J mouse groups (n = 1 mouse per group) were compared based on sex and sociability. Specific high confidence (HC) SFARI ASD risk DEGs are labeled in the plots. (B) Gene Ontology Biological Process (GO BP) enrichment analysis of ASD-related pathways in mature oligodendrocytes and microglia when C58/J mouse groups were compared based on sex and sociability. Pathways shown were significant (FDR q-value < 0.05) and were upregulated in ML and FH. Female Low Social, FL; Male High Social, MH

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Behavioral and Brain Functions

ISSN: 1744-9081

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