Fig. 5
From: Nucleus accumbens ghrelin signaling controls anxiety-like behavioral response to acute stress
Overexpression of GHSR in the NAc core reverses acute restraint stress-induced anxiogenic effects. A A sagittal brain section showing the microinjection site of AAV in the NAc core and a coronal section showing AAV expression in the NAc core. B Identification of the overexpression efficiency of GHSR mRNA by qRT-PCR. C-G Overexpression of GHSR in the NAc core increased the % time in open arms, the percentage of open arm entries, the time spent in the light box and the time in center area of acute restraint stressed rats. Data are shown as means ± SD; *** P < 0.001 for the comparison with the AAV-Control-oe group; # P < 0.05, ## P < 0.01 for the comparison with the stress + AAV-Control-oe group. aca, anterior commissure, anterior part