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Fig. 2 | Behavioral and Brain Functions

Fig. 2

From: Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure

Fig. 2

Nicotine alters dendritic spine morphology in the MSN. (A) DiI staining of MSN in the CPu and three types of dendritic spines: From the top right, thin spines/filopodia (blue arrows), a mushroom spine (yellow arrow), and a stubby spine (green arrow). (B, C) Repeated, not acute, nicotine exposure decreased the number of mushroom/stubby spines, while it increased thin spines/filopodia. (D) Neither repeated nor acute nicotine exposure affected the density of the spines. (E) Distribution of dendritic spines in each group. n = 1780 (Repeated saline), 1819 (Acute nicotine) and 1959 (Repeated nicotine) spines. N = 4 rats per group. *p < 0.05

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Behavioral and Brain Functions

ISSN: 1744-9081

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