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Fig. 3 | Behavioral and Brain Functions

Fig. 3

From: Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure

Fig. 3

Inhibition of cofilin restores the nicotine-induced change in dendritic spine morphology. (A) Bilateral intra-CPu infusion of cytochalasin D (CytoD) was confirmed by reconstructing the microinjection placements. (B, C) Inhibition of cofilin by CytoD restored the changes in mushroom spines and thin spines/filopodia after repeated nicotine exposure. (D) Inhibition of cofilin did not affect the density of the spine. (E) Distribution of dendritic spines in each group. n = 3183 (Vehicle + saline), 2793 (CytoD + saline), 2594 (Vehicle + nicotine) and 2413 (CytoD + nicotine) spines. N = 4 rats per group. *p < 0.05

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Behavioral and Brain Functions

ISSN: 1744-9081

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