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Fig. 4 | Behavioral and Brain Functions

Fig. 4

From: Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure

Fig. 4

Blockade of GluN2B subunits restores the nicotine-induced increase in cofilin activity. (A) Repeated nicotine exposure increased the expression of both surface- and intracellular GluN2B subunits. N = 4 rats per group. (B) Bilateral intra-CPu infusion of the GluN2B subunit antagonist, Ro 25-6981 (Ro), was confirmed by reconstructing microinjection placements. (C) Blockade of the GluN2B subunits with Ro elevated the repeated nicotine-induced decrease in pCofilin-IR. N = 3 rats per group. *p < 0.05

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Behavioral and Brain Functions

ISSN: 1744-9081

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