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Fig. 7 | Behavioral and Brain Functions

Fig. 7

From: Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure

Fig. 7

A diagram illustrating the nicotine-induced spine remodeling via GluN2B subunits-linked cofilin activity in the MSN. The elevation of glutamate release after repeated nicotine exposure leads to a reduction of pLIMK and subsequent pCofilin, which enables the active state of cofilin from its inactive state. Activation of cofilin in turn drives spine shrinkage from mushroom spines into thin spines/filopodia by increasing actin turnover

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Behavioral and Brain Functions

ISSN: 1744-9081

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