Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation

Li, Xiang; Ding, Qingyong; Wan, Xinxin; Wu, Qilong; Ye, Shiqing; Lou, Yongliang

doi:10.1186/s12993-024-00265-8

Fig. 5

From: Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation

Alterations of inflammatory cytokine levels in the plasma from APP/PS1 mice after FMT treatment. (A) The level of IL-6 (F = 8.257; P = 0.0092; df = 11) (n = 4 for each group) in plasma by ELISA kit. (B) The level of IL-1β (F = 6.622; P = 0.0234; df = 9) (WT, n = 3; APP/PS1, n = 3; APP/PS1 + FMT, n = 4) in plasma by ELISA kit. (C) The level of TNF-α (F = 14.20; P = 0.0016; df = 11) (n = 4 for each group) in plasma by ELISA kit. All data were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data were expressed as mean ± SD. *P < 0.05; **P < 0.01

Back to article page

Fig. 5

Behavioral and Brain Functions

Contact us