Fig. 2

TrkB knockdown within BLA showed higher proportion of affected individuals and impaired fear extinction memory while cued fear conditioning remained unaltered. (a) Total distance moved in the open field arena and anxiety index of distance did not differ between the CTR (n = 16) and TrkBKD (n = 22) groups. b Total traveled distance and anxiety index of distance in the elevated plus maze significantly different between the CTR and TrkBKD groups. c Behavioral profiling based on anxiety-like behavior in OF and EPM revealed an increased proportion of ‘affected’ rats in the TrkBKD group compared to the CTR group. Values are the % ‘unaffected’ and ‘affected’ animals in each group. d Acquisition of fear to the auditory conditioned stimulus (CS) paired with shock, measured as % freezing to the CS, did not differ between CTR (n = 16) and TrkBKD (n = 22) groups. e Difference in freezing behaviorduring the extinction training showed reduced levels for freezing in CTR compared to TrkBKD group. f–h Total freezing (%) was gradually decreased from day 1 to day 3 in CTR animals compared to TrkB knockdown animals. Data displayed as means ± SEMs, *p < 0.05, **p < 0.01, ***p < 0.001