Fig. 3
TrkB knockdown results impaired LTP in the medial prefrontal cortex without affecting the synaptic plasticity in the hippocampus a Representative evoked field potential responses recorded in the mPFC of rats injected with CTR (n = 6) and TrkBKD (n = 8) groups before (black) and after theta burst stimulation (TBS) (gray dotted) of the vSub to induce LTP in the mPFC. b TBS to the vSub pathway induced a significant potentiation of mPFC field potentials in CTR animals, which was reduced in TrkBKD group. A significant difference in average percentage of LTP after TBS was found in the mPFC between CTR and TrkBKD groups. c Without prior behavioral tests, TBS of the vSub pathway induced a significant potentiation of mPFC field potentials in CTR (n = 4) animals, which was reduced in TrkBKD (n = 4) group (left); changes in average percentage of LTP after TBS in CTR and TrkBKD groups. d Representative evoked field potential responses recorded in the dentate gyrus of rats injected with CTR (n = 3) and TrkBKD (n = 5) group before (black) and after theta burst stimulation (TBS) (gray dotted) in the perforant pathway to induce LTP in the DG e After TBS to the perforant path both groups displayed a similar level of potentiation in the DG; percentage of average LTP in DG remained unaltered after TBS in CTR and TrkBKD groups. (Data are shown as means ± SEMs. ***p < 0.001)