Fig. 5

TrkB knockdown in combination with underwater trauma resulted in impaired synaptic plasticity in the vSub–mPFC pathway. a Representative evoked field potential responses recorded in the mPFC of rats injected with CTR (n = 5), CTR-UWT(n = 5) and TrkBKD-UWT (n = 6) groups before (black) and after theta burst stimulation (TBS) (gray dotted) in the vSub to induce LTP in the mPFC b TBS to the vSub pathway induced a significant potentiation of mPFC field potentials in CTR animals, which was reduced in CTR-UWT and TrkBKD-UWT groups; changes in average percentage of LTP after TBS in CTR and trauma-exposed (CTR-UWT and TrkBKD-UWT) groups. Data are shown as means ± SEMs, *p < 0.05, **p < 0.01, ***p < 0.001