Fig. 4

Anxiety-like response measured by the elevated plus maze. (A) Time spent in the open arms. Injured rats spent less time in the open arms compared with uninjured shams (p = 0.020). (B) Time spent in the closed arms. Injured rats spent more time in the closed arms compared with uninjured shams (p = 0.0002). denotes males, denotes females. Sham = 58 (Val/Val = 19, Val/Met = 18, Met/Met = 21), rmTBI = 54 (Val/Val = 16, Val/Met = 19, Met/Met = 19). Data presented as median/IQR. * indicates an effect of injury, p < 0.05, *** indicates an effect of injury, p < 0.001